Wetmore has created over 700 portraits of many distinguished and well-known subjects including: President Richard M. Nixon, Jack Nicklaus, Fred Couples, Dr. and Mrs. Norman Vincent Peale, Leon Uris, Princess Grace, Prince Rainier and Prince Albert of Monaco. Private commissions include: Ford, Wrigley, Hewlett, Bechtel, Post, Searle, Brock, Perkin, Baker, Duke, Gannett, The Lord Inchiquin in Ireland, and The Lord and Lady Tollemache of England.

His paintings are in the collections of:
The White House
The Royal Palace of Monaco
The Knessett in Jerusalem
Harvard University
Duke University
Emory University
Northwestern Universities
University of North Carolina, Chapel Hill, North Carolina
The University of Texas, Houston, Texas
Hunter Museum of American Art
Presbyterian Hospital, New York
Massachusetts General Hospital, Boston, Massachusetts
Children's Hospital, Boston, Massachusetts
Harvard Medical Center
Barnes Hospital, St. Louis, Missouri
The Buckley School
St. Georges School
St. Marks School
The McCallie School
The Boston Company
The Southern Company
Georgia Power Company
Hardee's, Inc.
Department of Labor, Washington, D.C. and others.

Wetmore earned a degree in art and continued his studies at the Art Students League in New York. He is a member of the Artist’s Fellowship of New York and the Oil Painters of America and is a member of the board of Overseers of Opera Boston. He is the founding and current chairman of the Portrait Society of America.

In 1978 and 1998, a collection of Wetmore's paintings was published in the best-selling art book, Promised Land, with text by noted author Leon Uris and Israeli statesman Abba Eban. Ireland - Portrayed by Gordon Wetmore, with text by the artist and a foreword by Princess Grace of Monaco appeared in 1980. Gordon Wetmore's Prayers for Boys and Girls was published in 1986. In 2004, Vanishing Kingdoms, with 20 portraits by Wetmore and text by Ambassador Walter J.P. Curley, was published in Ireland by Lilliput Press.

American Artist magazine has described Gordon Wetmore as, "a friendly, open person, uniquely suited to portrait painting". He is known for his accuracy and vivid interpretations of people. He captures the true character of his subjects and his brushwork flows with feeling and responsiveness towards each person he paints.